Caryophyllene

Caryophyllene (β-caryophyllene) is a bicyclic sesquiterpene and one of 2 isomers (the other being humulene). Its larger molecular structure makes it more stable than monoterpenes. Due to the stability and high flower yields, caryophyllene remains the most prevalent terpene in cannabis year-to-year. Caryophyllene is commonly recognized for its pungent, peppery bite.

Another unique feature of caryophyllene is that it interacts with the CB2 receptor in the endocannabinoid system. This is the reason why caryophyllene is widely regarded for its anti-inflammatory effects.

Caryophyllene may help mitigate the psychoactive effects of THC. Current research is examining the role of CBD and caryophyllene in treating substance abuse disorders.

Vaporization Point: 266℉

Aroma/Flavor

Spicy

Peppery

Woody

Clove

Sweet

Dry

Common Sources

Black Pepper

Hops

Cloves

Rosemary

Allspice

Cinnamon

Effects

Analgesia: anti-inflammation

Neuroprotective

Gastroprotective

Antiproliferative

Increase Bone Density

Decrease Cold Sensation (topical)

Disclaimer: This is not to be considered as medical advice, but rather educational material to guide therapuetic decisions. Talk to your local dispensary pharmacist about how terpenes can be used medicinally.

Resources:

Aly, Esraa, et al. “β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain.” Molecules, vol. 25, no. 1, 27 Dec. 2019, p. 106, https://doi.org/10.3390/molecules25010106.

“Caryophyllene - an Overview | ScienceDirect Topics.” Www.sciencedirect.com, www.sciencedirect.com/topics/medicine-and-dentistry/caryophyllene.

Cox-Georgian, Destinney, et al. “Therapeutic and Medicinal Uses of Terpenes.” Medicinal Plants, 12 Nov. 2019, pp. 333–359, www.ncbi.nlm.nih.gov/pmc/articles/PMC7120914/, https://doi.org/10.1007/978-3-030-31269-5_15.

Hudson, R. (2023). The Big Book of Terps: Understanding Terpenes and Synergy in Cannabis (J. Graddon, Ed.) (2nd ed.). Hudson Press.

“Perfumers Apprentice - Caryophyllene Beta (Natural).” Shop.perfumersapprentice.com, shop.perfumersapprentice.com/p-8629-caryophyllene-beta-natural.aspx. Accessed 31 May 2024.

“What Is Caryophyllene? What Does This Cannabis Terpene Do?” Sirona Pharma, 14 Sept. 2021, acreagepharms.ca/what-is-caryophyllene/. Accessed 31 May 2024.