Cannabidiol (CBD)
CBD
Cannabidiol (CBD) is the main non-psychoactive compound found in the cannabis plant. It has many molecular targets that involve its activity with many physiological pathways. Unlike THC, it is not psychoactive and does not produce a "high" sensation. In fact, CBD has the potential to act as a THC buffer, meaning that it can mitigate the psychoactive effects of THC. CBD is typically extracted from the hemp plant, which contains only trace amounts of THC. It can also be extracted from CBD-producing cannabis strains and found in medical marijuana products.
CBD products are often identified as "full-spectrum" or "broad-spectrum." Full spectrum means that there may be trace amounts of THC along with other cannabinoids, whereas broad-spectrum refers to CBD products with no THC at all.
CBD has a range of potential therapeutic benefits, including pain relief, reducing anxiety and depression, improving sleep quality, and reducing inflammation. It works by interacting with the body's endocannabinoid system. In fact, CBD has been identified as a pleiotropic molecule, meaning it works through many biochemical pathways, including over 65 molecular targets.
Studies have shown that CBD has the potential to reduce seizures in people with epilepsy, and it is approved by the U.S. Food and Drug Administration (FDA) for this purpose. CBD has also been shown to have anti-inflammatory properties and may help treat autoimmune conditions and others, such as arthritis, multiple sclerosis, and inflammatory bowel disease.
Effects
Anxiolytic
Antidepressant
Analgesia
Antiemetic
Appetite Suppression
Reduce THC impairment
Functions
Regulate Endocannabinoid Tone
Neuroprotection
Metabolic regulation
Immune: anti-inflammatory
Cardioprotection
Antiproliferation/antitumor
Anticonvulsive
Adverse Effects
Sedation
Diarrhea
Loss of appetite
Dosing
Dosing CBD can vary depending on the individual and the condition being treated, and it is always recommended to consult a cannabis healthcare professional before using CBD.
Some effects are dose-dependent, meaning low doses and high doses will elicit different experiences. This is usually noticed with energy/clarity at lower doses and relaxation at higher doses.
In general:
Microdose = 5 mg and below
Mild pain and inflammation
Headaches, mood stabilizing, nausea, metabolic disorders
Low dose = 5 - 10 mg
Anxiety, PTSD, depression
Standard dose = 10 - 25 mg
Mild to moderate pain and inflammation
Anxiety, PTSD, depression
High dose = 25 - 100 mg
Moderate to severe pain and inflammation
Autoimmune diseases, severe arthritis, Lyme, fibromyalgia, MS, IBS
Insomnia
Appetite suppression
Macro dose = 100 - 1000 mg
Cancer, epilepsy